Olagide Wagner Castro

Universidade Federal de Alagoas – Maceió, Brasil.

Laboratório de Farmacologia e Fisiologia Integrativa.

LECTURE: Experimental and Ethnopharmacological Characterization of Substances with Anti-Epileptogenic and Neuroprotective Actions.

The hippocampus is one of the most susceptible regions in the brain to be distraught with Status Epilepticus (SE) induced injury. SE can occur from multiple causes and is more frequent in children and the elderly population. Administration of a combination of antiepileptic drugs (AED) can abolish acute seizures in most instances of SE but cannot prevent the morbidity typically seen after SE such as cognitive and memory impairments and spontaneous recurrent seizures (SRS).

This is primarily due to the inefficiency of AED to modify the evolution of SE-induced initial precipitating injury into epileptogenic changes followed by SRS, cognitive and memory impairments, associated with chronic inflammation, significantly waned neurogenesis and abnormal synaptic reorganization. Thus, alternative approaches that are efficient not only for curtailing SE-induced initial brain injury and its complex neuroplastic phenomena, but also for restraining the progression of SE into a chronic epileptic state are needed.

Olagide W. Castro will introduce three emerging therapies for preventing or easing SE-induced neurodegeneration, neuroinflammation, cognitive and memory impairments. Specifically, therapeutic efficacy of the natural products Resveratroland Citrus limon essential oil, and the effect of reduction in glucose metabolism restricted to the hippocampus, by inhibition of Na+/glucosecotransporters( SGLTs) using intrahippocampal administration of phlorizin PZN before pilocarpine-induced SE will be discussed.