Antônio Carlos Roque da Silva Filho

Universidade de São Paulo – Ribeirão Preto, Brasil.

Departamento de Física Médica, FFCLRP.

LECTURE: Computational Neuroscience and the Epilepsies.

Temporal lobe epilepsy (TLE) provokes a number of different morphological alterations in granule cells of the hippocampus dentate gyrus. These alterations may be associated with the hyperactivity and hypersynchrony found in the epileptic dentate gyrus, and its study requires the use of different kinds of approaches including computational modeling.

Conductance-based models of both normal and epilepsy-induced morphologically altered granule cells have been used in the construction of network models of dentate gyrus to study the effects of these alterations on epilepsy.

In his presentation, Antonio Carlos Roque will review these models and discuss their contributions to the understanding of the association between alterations in neuronal morphology and epilepsy.